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SUMMARY: Exelixis is dedicated to building a world-class Structural Biology group to accelerate the discovery and development of novel therapeutics to fight cancer. We are seeking a highly skilled and motivated electron microscopist to supervise the installation and operation of a G4 CFEG Titan Krios electron microscope. The successful candidate will have extensive experience in cryogenic electron microscopy (cryoEM) with a demonstrated track record operating and maintaining modern high-end electron microscopes. A strong background in other aspects of cryoEM such as sample preparation, data collection, processing, and model building is highly desired. Strong communication and collaboration skills are required as this position will interact extensively across discovery departments and teams.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Oversee the installation of a G4 CFEG Titan Krios with a SelectrisX and Falcon4i
- Operate the Titan Krios and associated sample preparation instruments to support high-resolution single-particle sample preparation and data collection
- Collaborate with members of the Protein Science team to optimize cryoEM of challenging samples
- Enable high resolution cryoEM structures of a diverse set of targets to support structure-based drug discovery
- Develop, evaluate, optimize, and implement new technologies and data collection strategies to keep up to date with scientific advancements in the field
- Develop documentation and training procedures for all aspects of the cryoEM workflow
- Coordinate with IT to support computational infrastructure for the electron microscopy facility
- Help train staff to prepare cryoEM samples and operate the electron microscope
- Maintain laboratory notebooks in accordance with company policies and practices
- Comply with safe laboratory practices and EH&S guidelines
- Contribute to the writing of technical documents, patents, scientific manuscripts, etc.
SUPERVISORY RESPONSIBILITIES:
- Help train staff to prepare cryoEM samples and operate the electron microscope
EDUCATION & EXPERIENCE:
- Ph.D. in structural biology, biophysics, biochemistry, or a related field with a clear track record of operating electron microscopes and solving challenging structures, and a minimum of 2 years of post-PhD experience; or,
- Equivalent combination of education and experience.
ADDITIONAL SKILLS & ABILITIES:
- A minimum of at least 4-years of experience operating cryogenic electron microscopes is required
- Experience with a wide range of sample preparation techniques to overcome issues with challenging samples is highly desired
- Experience working with multiple data processing packages and applying new computational techniques to address conformational/compositional sample heterogeneity is highly desired
- Experience working with service engineers to maintain functional electron microscopes is highly desired
- Experience with EPU for automated data collection is a plus
- Experience working with medicinal chemists to translate cryoEM structures into actionable data for structure-based drug design of small molecules is a plus
- Experience with micro-ED sample prep and data acquisition is a plus
- Strong written, oral and presentation communication skills
DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!
Our compensation reflects the cost of labor across severalU.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this positionis $125,000 - $176,500 annually. The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors.In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.